PhD Candidate
VARVARA PLATANIA
vplatania@materials.uoc.gr
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Title
Angiogenic and Osteogenic Potential of Cells in Three-Dimensional Scaffolds for Bone Regeneration
Supervisor
CHATZINIKOLAIDOU MARIA, Associate Professor, Materials Science & Technology Dept. - UOC
Committee Members
PONTIKOGLOU CHARALAMPOS, Associate Professor, School of Medicene - UOC
ROUMPELAKI ΜΑΡΙΑ, Associate Professor, Biology Lab, Medicine Dept. - UOA
Abstract
Large bone defects are a major clinical and socioeconomic problem, as they negatively impact patients’ quality of life. Osteogenesis and vascularization are coupled during bone development and growth. Several studies have investigated the combined effect of osteogenic and angiogenic growth factors on differentiation of mesenchymal stem cells. However, the integration of a fully functional vascular network inside bone grafts remains a biological and engineering challenge. The general objective of PhD is to develop a multifunctional platform to crosstalk in co-culture and promote the reconstruction of vascularized bone, which is crucial to treat large bone defects.