PhD Candidate
MICHAIL MILONAKIS
milmikis@materials.uoc.gr
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Title
Wavefront Shaping for Microscopic Imaging of Biological Samples
Supervisor
PAPAZOGLOU DIMITRIOS, Associate Professor, Materials Science & Technology Dept. - UOC
Committee Members
TZORTZAKIS STILIANOS, Professor, Materials Science & Technology Dept. - UOC
ZACHARAKIS IOANNIS, Researcher B, FORTH, Heraklion Crete GREECE
Abstract
Imaging of biological samples is one of the driving application fields of optical microscopy. Although several other imaging techniques have been developed the simplicity, the effectiveness and the non-invasive nature of optical microscopy are the key factors of its widespread use in Biology. An important limiting factor for optical microscopy is the scattering of light as it propagates through biological tissue. The inherent random variations of the optical properties, lead to a diffusion dominated propagation that drastically limits the effective imaging range down to 1 mm. On the other hand, recent advances in the spatial modulation of the light beam that illuminates the sample combined with analysis of the detected light distribution have opened the way to beat the diffusion limit. The goal of this PhD thesis is to increase the effective imaging range in diffusive samples by combining, in an adaptive dynamic loop, high resolution spatial wavefront and/or polarization control with high speed sophisticated fuzzy logic numerical processing of the feedback from the scattered light detection.