Διάλεξη

Τετάρτη 25 Απριλίου 2012

Ομιλητής
Estelle Mossou
Ίδρυμα
Partnership for Structural Biology, Institut Laue-Langevin / Keele University
Τίτλος
Multidisciplinary approaches for structural studies in biological fibres, solutions and crystals
Χώρος
Κτήριο Φυσικού, Βούτες, Αιθ. Σεμιναρίων 3ου ορόφου
Ώρα
11:00
Γλώσσα
Αγγλικά
Περίληψη

The Partnership for Structural biology in Grenoble is situated at the heart of the European photon and neutron science campus (EPN) and benefits from a powerful range of techniques and expertise. The proximity of the ILL (with its world-leading neutron source) and the ESRF (one of the most intense synchrotron X-ray source in the world) allows cutting-edge interdisciplinary research to be carried out in the biosciences and biotechnology. This talk will describe capabilities and platforms that are available to users of the EPN campus, as well as some specific examples of structural studies of biological systems in fibrous, solution, and crystalline samples. One area of particular interest that is the subject of a collaboration with academics at Crete relates to structural studies of amyloid-forming peptides. The extent of the information available from fibre diffraction is variable and highly dependent on sample crystallinity and orientation. However, in many situations, even when the overall information content is low, fibre diffraction patterns can often be used as a reliable fingerprint in structural characterisation - for example the cross-beta amyloid fibre diffraction pattern gives a highly characteristic fibre pattern that is used very effectively as part of the diagnosis of amyloid. Furthermore the potential of neutron methods to probe unique aspects of amyloid structure has the potential to provide further information alongside that available through the use of X-ray methods.